Abstract
A strategy has been developed for switching chemical reactions between two identical reagents on the basis of DNA duplex-triplex transition. In response to the change of solution pH, a DNA complex changes its conformation and repositions chemical reagents that are conjugated with DNA strands. As a result, chemical reactions are reprogrammed. This strategy is expected to be applicable to sophisticated chemical syntheses.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acylation
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Amines / chemistry*
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Amines / metabolism
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Carboxylic Acids / chemistry*
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Carboxylic Acids / metabolism
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Cytosine / chemistry
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Cytosine / metabolism
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DNA / chemistry*
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DNA / metabolism
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Electrophoresis, Polyacrylamide Gel
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Hydrogen-Ion Concentration
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Nucleic Acid Conformation
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Structure-Activity Relationship
Substances
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Amines
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Carboxylic Acids
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triplex DNA
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Cytosine
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DNA