Reprogramming DNA-directed reactions on the basis of a DNA conformational change

J Am Chem Soc. 2004 Oct 20;126(41):13240-1. doi: 10.1021/ja045718j.

Abstract

A strategy has been developed for switching chemical reactions between two identical reagents on the basis of DNA duplex-triplex transition. In response to the change of solution pH, a DNA complex changes its conformation and repositions chemical reagents that are conjugated with DNA strands. As a result, chemical reactions are reprogrammed. This strategy is expected to be applicable to sophisticated chemical syntheses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acylation
  • Amines / chemistry*
  • Amines / metabolism
  • Carboxylic Acids / chemistry*
  • Carboxylic Acids / metabolism
  • Cytosine / chemistry
  • Cytosine / metabolism
  • DNA / chemistry*
  • DNA / metabolism
  • Electrophoresis, Polyacrylamide Gel
  • Hydrogen-Ion Concentration
  • Nucleic Acid Conformation
  • Structure-Activity Relationship

Substances

  • Amines
  • Carboxylic Acids
  • triplex DNA
  • Cytosine
  • DNA