Abstract
The study was designed to investigate the influence of hydroxyurea (HU) treatment on PRV-1 expression. Eighteen newly diagnosed patients with essential thrombocythemia (ET) or polycythemia vera (PV) were included. HU significantly increased PRV-1 gene expression in the early stage of treatment.
MeSH terms
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Aged
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Aged, 80 and over
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Biomarkers
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Computer Systems
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Female
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GPI-Linked Proteins
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Humans
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Hydroxyurea / pharmacology*
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Hydroxyurea / therapeutic use
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Isoantigens / biosynthesis*
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Isoantigens / blood
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Isoantigens / genetics
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Male
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Membrane Glycoproteins / biosynthesis*
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Membrane Glycoproteins / blood
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Membrane Glycoproteins / genetics
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Middle Aged
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Platelet Count
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Polycythemia Vera / blood
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Polycythemia Vera / drug therapy*
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Polycythemia Vera / genetics
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RNA, Messenger / biosynthesis
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RNA, Messenger / blood*
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Receptors, Cell Surface / biosynthesis*
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Receptors, Cell Surface / blood
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Receptors, Cell Surface / genetics
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Reverse Transcriptase Polymerase Chain Reaction
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Thrombocythemia, Essential / blood
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Thrombocythemia, Essential / drug therapy*
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Thrombocythemia, Essential / genetics
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Up-Regulation / drug effects*
Substances
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Biomarkers
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CD177 protein, human
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GPI-Linked Proteins
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Isoantigens
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Membrane Glycoproteins
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RNA, Messenger
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Receptors, Cell Surface
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Hydroxyurea