The effects of hydroxyurea on PRV-1 expression in patients with essential thrombocythemia and polycythemia vera

Haematologica. 2004 Oct;89(10):1264-6.

Abstract

The study was designed to investigate the influence of hydroxyurea (HU) treatment on PRV-1 expression. Eighteen newly diagnosed patients with essential thrombocythemia (ET) or polycythemia vera (PV) were included. HU significantly increased PRV-1 gene expression in the early stage of treatment.

Publication types

  • Letter

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers
  • Computer Systems
  • Female
  • GPI-Linked Proteins
  • Humans
  • Hydroxyurea / pharmacology*
  • Hydroxyurea / therapeutic use
  • Isoantigens / biosynthesis*
  • Isoantigens / blood
  • Isoantigens / genetics
  • Male
  • Membrane Glycoproteins / biosynthesis*
  • Membrane Glycoproteins / blood
  • Membrane Glycoproteins / genetics
  • Middle Aged
  • Platelet Count
  • Polycythemia Vera / blood
  • Polycythemia Vera / drug therapy*
  • Polycythemia Vera / genetics
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / blood*
  • Receptors, Cell Surface / biosynthesis*
  • Receptors, Cell Surface / blood
  • Receptors, Cell Surface / genetics
  • Reverse Transcriptase Polymerase Chain Reaction
  • Thrombocythemia, Essential / blood
  • Thrombocythemia, Essential / drug therapy*
  • Thrombocythemia, Essential / genetics
  • Up-Regulation / drug effects*

Substances

  • Biomarkers
  • CD177 protein, human
  • GPI-Linked Proteins
  • Isoantigens
  • Membrane Glycoproteins
  • RNA, Messenger
  • Receptors, Cell Surface
  • Hydroxyurea