[Detecting microdeletions of the Y chromosome in patients with high follicle-stimulating hormone azoospermia]

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004 Oct;21(5):485-7.
[Article in Chinese]

Abstract

Objective: To explore the relationship between the patients' high follicle-stimulating hormone (FSH) azoospermia and microdeletions in Y chromosome.

Methods: Eleven sequence tagged sites (STSs) in Yq were detected by PCR in 16 male patients' high FSH azoospermia.

Results: Microdeletions were observed in 6 of 16 male patients and the deletion rate was 37.5%(6/16). Five types of microdeletions were detected: AZFc(SY152), AZFc (SY152+SY254)+AZFd (SY153), AZFc (SY152+SY254+SY255)+AZFd (SY153), AZFc (SY152+SY158+SY255)+AZFd (SY153),and AZFb (SY130)+AZFc (SY158+SY254+SY255)+AZFd (SY153) respectively.

Conclusion: Microdeletion of Y chromosome was one of the important reasons of the patients' high FSH azoospermia. Before the application of assisted-reproductive technology (ART) to the patients, it is necessary to detect the microdeletions, especially AZFc and AZFd.

Publication types

  • English Abstract

MeSH terms

  • Azoospermia / genetics*
  • Azoospermia / metabolism
  • Chromosome Deletion
  • Chromosomes, Human, Y / genetics*
  • Female
  • Follicle Stimulating Hormone / metabolism*
  • Humans
  • Infertility, Male / genetics*
  • Infertility, Male / metabolism
  • Male
  • Polymerase Chain Reaction
  • Sequence Tagged Sites

Substances

  • Follicle Stimulating Hormone