Semi-parametric estimation of the binormal ROC curve for a continuous diagnostic test

Biostatistics. 2004 Oct;5(4):573-86. doi: 10.1093/biostatistics/kxh009.

Abstract

Not until recently has much attention been given to deriving maximum likelihood methods for estimating the intercept and slope parameters from a binormal ROC curve that assesses the accuracy of a continuous diagnostic test. We propose two new methods for estimating these parameters. The first method uses the profile likelihood and a simple algorithm to produce fully efficient estimates. The second method is based on a pseudo-maximum likelihood that can easily accommodate adjusting for covariates that could affect the accuracy of the continuous test.

MeSH terms

  • Algorithms
  • CA-125 Antigen / blood
  • CA-19-9 Antigen / blood
  • Computer Simulation
  • Diagnostic Tests, Routine / methods
  • Diagnostic Tests, Routine / standards*
  • Humans
  • Likelihood Functions*
  • Male
  • Prostatic Neoplasms / diagnosis
  • ROC Curve*

Substances

  • CA-125 Antigen
  • CA-19-9 Antigen