Sudden infant death syndrome due to parainfluenza virus 2 associated with hemophagocytic syndrome

Yasuyo Kashiwagi; Hisashi Kawashima; Yuki Kanetaka; Hiroaki Ioi; Kouji Takekuma; Akinori Hoshika; Jun Matsubayashi; Kiyoshi Mukai

doi:10.1016/j.jinf.2003.10.002

Sudden infant death syndrome due to parainfluenza virus 2 associated with hemophagocytic syndrome

J Infect. 2004 Nov;49(4):329-32. doi: 10.1016/j.jinf.2003.10.002.

Authors

Yasuyo Kashiwagi¹, Hisashi Kawashima, Yuki Kanetaka, Hiroaki Ioi, Kouji Takekuma, Akinori Hoshika, Jun Matsubayashi, Kiyoshi Mukai

Affiliation

¹ Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. hoyohoyo@tokyo-med.ac.jp

PMID: 15474632
DOI: 10.1016/j.jinf.2003.10.002

Abstract

We report a child with Sudden Infant Death Syndrome (SIDS), aged 16 months. The histological findings of tonsils, spleen, and bone marrow revealed many hemophagocytic cells. Parainfluenza virus type 2 (PIV2) was cultured in the nasopharynx and detected by reverse-transcription (RT)-PCR in liver tissue and bone marrow. His laboratory data of elevated level of ferritin and IL-6 suggested hemophagocytic syndrome (HPS). It is suspected that PIV2 infection in infants is a risk factor for SIDS.

Publication types

Case Reports

MeSH terms

Histiocytosis, Non-Langerhans-Cell / complications*
Humans
Infant
Male
Parainfluenza Virus 2, Human / isolation & purification*
Rubulavirus Infections / complications*
Rubulavirus Infections / virology
Sudden Infant Death / etiology*