Cytogenetic findings in phyllodes tumor and fibroadenomas of the breast

Miriam L Barbosa; Enilze M S F Ribeiro; Guaracira F Silva; Marcos E Maciel; Rubens S Lima; Luciane R Cavalli; Iglenir J Cavalli

doi:10.1016/j.cancergencyto.2004.02.005

Cytogenetic findings in phyllodes tumor and fibroadenomas of the breast

Cancer Genet Cytogenet. 2004 Oct 15;154(2):156-9. doi: 10.1016/j.cancergencyto.2004.02.005.

Authors

Miriam L Barbosa¹, Enilze M S F Ribeiro, Guaracira F Silva, Marcos E Maciel, Rubens S Lima, Luciane R Cavalli, Iglenir J Cavalli

Affiliation

¹ Departamento de Genética, Universidade Federal do Paraná, Centro Politécnico, Jardim das Américas, Curitiba, Paraná, Brazil, 80.000.

PMID: 15474152
DOI: 10.1016/j.cancergencyto.2004.02.005

Abstract

The cytogenetic data on fibroadenomas and cystosarcoma phyllodes tumor of the breast, which are both biphasic breast tumors composed of epithelial and stromal components, are quite limited. In this study, we report on clonal chromosomal alterations in three fibroadenomas and one cystosarcoma phyllodes analyzed by GTG banding. The fibroadenomas presented mostly numerical abnormalities involving chromosomes 16, 18, and 21. One case presented a deletion on 17p. The cystosarcoma phyllodes presented numerous numerical abnormalities, mostly chromosome gains, and several marker chromosomes.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Breast Neoplasms / genetics*
Chromosome Aberrations*
Female
Fibroadenoma / genetics*
Humans
Karyotyping
Phyllodes Tumor / genetics*