A protocol to select high quality datasets of ecotoxicity values for pesticides

J Environ Sci Health B. 2004 May;39(4):641-52. doi: 10.1081/pfc-200026890.

Abstract

The key to any QSAR model is the underlying dataset. In order to construct a reliable dataset to develop a QSAR model for pesticide toxicity, we have derived a protocol to critically evaluate the quality of the underlying data. In developing an appropriate protocol that would enable data to be selected in constructing a QSAR, we concentrated on one toxicity end point, the 96 h LC50 from the acute rainbow trout study. This end point is key in pesticide regulation carried out under 91/414/EEC. The dataset used for this exercise was from the US EPA-OPP database.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Data Collection / standards*
  • Endpoint Determination
  • Environmental Pollutants / toxicity*
  • Lethal Dose 50
  • Models, Theoretical*
  • Oncorhynchus mykiss
  • Pesticides / toxicity*
  • Quantitative Structure-Activity Relationship
  • Reproducibility of Results
  • Risk Assessment

Substances

  • Environmental Pollutants
  • Pesticides