Sensory neuropathy revealing necrotizing vasculitis during infliximab therapy for rheumatoid arthritis

J Rheumatol. 2004 Oct;31(10):2079-81.

Abstract

We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Monoclonal* / adverse effects
  • Antibodies, Monoclonal* / therapeutic use
  • Antirheumatic Agents* / adverse effects
  • Antirheumatic Agents* / therapeutic use
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / pathology
  • Female
  • Humans
  • Infliximab
  • Middle Aged
  • Neurons, Afferent / pathology*
  • Polyradiculoneuropathy / pathology*
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Vasculitis, Central Nervous System* / chemically induced
  • Vasculitis, Central Nervous System* / pathology

Substances

  • Antibodies, Monoclonal
  • Antirheumatic Agents
  • Tumor Necrosis Factor-alpha
  • Infliximab