Patients undergoing radical cystectomy with an ileal neobladder need intensive follow-up due to the recent studies concerning the potential neoplastic transformation of the intestinal mucosa. We report a case of a gross hematuria due to a lesion that developed in an ileal orthotopic bladder 10 years after a nerve and seminal sparing radical cystectomy for transitional bladder cancer. We performed a transurethral resection of the lesion and histopathological evaluation revealed an adenomatous polyp. In our case transurethral resection of the adenoma seems to be a safe and conservative approach in the management of these lesions, however further follow-up is requested.