Abstract
Phytochemical study of the ethanol extract of the seeds of Aesculus chinensis led to the isolation of a new triterpenoid saponin (6), together with five known triterpenoid saponins (1-5). The structure of the new compound was elucidated on the basis of spectral data to be 21,28-di-O-acetylprotoaescigenin-3-O-[beta-D-glucopyranosyl(1-2)][beta-D-glucopyranosyl(1-4)]-beta-D-glucopyranosiduronic acid (aesculiside A, 6). The antiinflammatory activities of the four main saponins (1-4) were compared with those of total saponin extracts, and single saponins showed more potent activity than total saponin extracts in mice.
MeSH terms
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Aesculus*
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Chromatography, High Pressure Liquid
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Edema / chemically induced
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Edema / drug therapy
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Female
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Magnetic Resonance Spectroscopy
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Male
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Mice
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Molecular Structure
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Plant Extracts
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Saponins / chemistry
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Saponins / isolation & purification
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Saponins / pharmacology*
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Seeds
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
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Xylenes / adverse effects
Substances
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21,28-di-O-acetylprotoaescigenin-3-O-(beta-D-glucopyranosyl(1-2)9beta-D-glucopyranosyl(1-4))-beta-D-glucopyranosiduronic acid
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Anti-Inflammatory Agents
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Plant Extracts
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Saponins
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Triterpenes
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Xylenes