Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disorders. Recently, several forms of familial PD have been reported so far. Among them, several causative genes such as alpha-synuclein, UCH-L1, PINK1, and DJ-1 have been identified. Functional analysis on these causative genes may help us to explore the molecular mechanisms of nigral neuronal death in not only FPD but also sporadic form of PD. Thus, the identification of FPD gives us good information of etiologies of PD.
MeSH terms
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Humans
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Intracellular Signaling Peptides and Proteins
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Nerve Tissue Proteins / genetics
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Oncogene Proteins / genetics
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Parkinson Disease / genetics*
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Protein Deglycase DJ-1
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Protein Kinases / genetics
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Synucleins
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Ubiquitin Thiolesterase / genetics
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Ubiquitin-Protein Ligases / genetics
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alpha-Synuclein
Substances
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Intracellular Signaling Peptides and Proteins
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Nerve Tissue Proteins
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Oncogene Proteins
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SNCA protein, human
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Synucleins
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UCHL1 protein, human
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alpha-Synuclein
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Ubiquitin-Protein Ligases
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parkin protein
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Protein Kinases
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PTEN-induced putative kinase
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PARK7 protein, human
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Protein Deglycase DJ-1
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Ubiquitin Thiolesterase