Influence of marginal and segmental mandibular resection on the survival rate in patients with squamous cell carcinoma of the inferior parts of the oral cavity

J Craniomaxillofac Surg. 2004 Oct;32(5):318-23. doi: 10.1016/j.jcms.2004.05.005.

Abstract

Aim: The aim of this retrospective study was to investigate whether radical (segmental resection) or conservative (marginal) resection of mandibular bone influenced patients, survival.

Patients and methods: A series of 136 patients selected for partial mandibular resection for the treatment of squamous cell carcinomas of the lower oral cavity was evaluated retrospectively. Fifty-four patients underwent marginal and 82 cases segmental resection of the mandible. The mean follow-up periods were 91.1+/-30.1 months and 91.5+/-26.2 months, respectively. Data was extracted from the patient records and transferred into a database for statistical evaluation. Results Mean survival was 63.0+/-35.3 months for marginal and 53.1+/-32.3 months for segmental resection. The overall survival rate was analysed according to Kaplan-Meier and the test of significance (Log Rank) which yielded no statistically significant difference in the survival rate between both groups (p=0.1119). Numbers of recurrences, second primaries, metastases and/or postoperative complications were similar in both groups, i.e. no statistically significant differences were observed (ANOVA, Post-hoc Scheffé test). Conclusion In cases with an indication for bone resection, marginal resection may achieve satisfactory control and is as effective as segmental resection.

MeSH terms

  • Analysis of Variance
  • Carcinoma, Squamous Cell / secondary
  • Carcinoma, Squamous Cell / surgery*
  • Chemotherapy, Adjuvant
  • Female
  • Follow-Up Studies
  • Humans
  • Linear Models
  • Male
  • Mandible / surgery*
  • Mouth Floor / surgery*
  • Mouth Neoplasms / surgery*
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Staging
  • Neoplasms, Second Primary / pathology
  • Postoperative Complications
  • Radiotherapy, Adjuvant
  • Retrospective Studies
  • Survival Rate