Tools for glycomics: mapping interactions of carbohydrates in biological systems

Chembiochem. 2004 Oct 4;5(10):1375-83. doi: 10.1002/cbic.200400106.

Abstract

The emerging field of glycomics has been challenged by difficulties associated with studying complex carbohydrates and glycoconjugates. Advances in the development of synthetic tools for glycobiology are poised to overcome some of these challenges and accelerate progress towards our understanding of the roles of carbohydrates in biology. Carbohydrate microarrays, fluorescent neoglycoconjugate probes, and aminoglycoside antibiotic microarrays are among the many new tools becoming available to glycobiologists.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Carbohydrate Metabolism*
  • Carbohydrate Sequence
  • Carbohydrates / analysis
  • Carbohydrates / chemistry*
  • Glycosylation
  • Humans
  • Molecular Probes / chemical synthesis
  • Molecular Probes / chemistry
  • Molecular Sequence Data
  • Nucleic Acids / analysis
  • Nucleic Acids / chemistry
  • Nucleic Acids / metabolism
  • Polysaccharides / analysis
  • Polysaccharides / chemistry*
  • Polysaccharides / metabolism*
  • Proteins / analysis
  • Proteins / chemistry
  • Proteins / metabolism
  • Surface Plasmon Resonance / methods

Substances

  • Carbohydrates
  • Molecular Probes
  • Nucleic Acids
  • Polysaccharides
  • Proteins