Effect of certain compositions of heavy metals on the course of the system infection of TMV in plants of tomatoes Lycopersicon esculentum L. under field conditions was investigated. It is shown that the simultaneous influence of the virus infection and heavy metals in concentration of 10 MPC (maximum permissible concentration) resulted in the decrease of the content of total chlorophyll in the investigated plants by degradation of chlorophyll A; that was more considerable decrease as compared with separate influence of each of the factors. Treatment of plants by toxical concentrations of lead and zinc led to inconsiderable delay in development of the system TMV infection together with the increase of the virus content in plants 2 and more times, that evidences for the probable synergism in the action of the given heavy metals and virus infection. On the contrary, copper, though it decreased the content of total chlorophyll, manifested the protective properties and restricted essentially the virus accumulation in a plant as a whole.