The Citizen Health System (CHS) is a European Commission (CEC) funded project in the field of IST for Health. Its main goal is to develop a generic contact center which in its pilot stage can be used in the monitoring, treatment, and management of chronically ill patients at home in Greece, Spain, and Germany. Such contact centers, using any type of communication technology, and providing timely and preventive prompting to the patients, are envisaged in the future to evolve into well-being contact centers providing services to all citizens. In this paper, we present the structure of such a generic contact center and in particular the telecommunication infrastructure, the communication protocols and procedures, and finally the educational modules that are integrated into this contact center. We present the procedures followed for two target groups of patients, namely diabetic patients, and congestive heart failure patients, in which two randomized controlled clinical trials are under way. We present examples of the communication means between the contact center medical personnel and these patients, and elaborate on the educational, user, and telecommunication issues involved.