Pasteurella multocida toxin as a tool for studying Gq signal transduction

Rev Physiol Biochem Pharmacol. 2004:152:93-109. doi: 10.1007/s10254-004-0032-6. Epub 2004 Sep 29.

Abstract

Pasteurella multocida toxin (PMT) stimulates and subsequently uncouples phospholipase C (PLC) signal transduction through its selective action on the Galphaq subunit. This review summarizes what is currently known about the molecular action of PMT on Gq and the resulting cellular effects. Examples are presented illustrating the use of PMT as a powerful tool for dissecting the molecular mechanisms involving pertussis toxin (PT)-insensitive heterotrimeric G proteins.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bacterial Proteins / pharmacology*
  • Bacterial Toxins / pharmacology*
  • Enzyme Activation
  • GTP-Binding Protein alpha Subunits, Gq-G11 / metabolism*
  • Signal Transduction / drug effects*
  • Type C Phospholipases / metabolism

Substances

  • Bacterial Proteins
  • Bacterial Toxins
  • Pasteurella multocida toxin
  • Type C Phospholipases
  • GTP-Binding Protein alpha Subunits, Gq-G11