Nitroxide synthase activity as a marker of early stages of experimental cartilage dysmetabolism

A V Cherepovskii; A I Dubikov; S V Nikulin; L A Belogolovykh; E E Medved

doi:10.1023/b:bebm.0000038168.59013.8f

Nitroxide synthase activity as a marker of early stages of experimental cartilage dysmetabolism

Bull Exp Biol Med. 2004 May;137(5):517-20. doi: 10.1023/b:bebm.0000038168.59013.8f.

Authors

A V Cherepovskii¹, A I Dubikov, S V Nikulin, L A Belogolovykh, E E Medved

Affiliation

¹ Vladivostok State Medical Institute.

PMID: 15455133
DOI: 10.1023/b:bebm.0000038168.59013.8f

Abstract

Time course of nitroxide synthase activity in the knee joint cartilage was studied in animals with experimental anterior instability of the knee joint. A significant increase in nitroxide synthase activity in chondrocytes was paralleled by a progressive decrease in glycosaminoglycan content in the cartilaginous matrix and subsequent destruction of the cartilage cytoarchitectonics.

MeSH terms

Animals
Biomarkers / analysis
Biomarkers / metabolism
Cartilage, Articular / enzymology
Cartilage, Articular / metabolism*
Cartilage, Articular / pathology
Chondrocytes / enzymology*
Chondrocytes / metabolism
Glycosaminoglycans / analysis
Glycosaminoglycans / metabolism
Joint Instability / enzymology
Joint Instability / metabolism*
Joint Instability / pathology
Knee Joint / metabolism
Male
Nitric Oxide / metabolism
Nitric Oxide Synthase / analysis
Nitric Oxide Synthase / metabolism*
Rats

Substances

Biomarkers
Glycosaminoglycans
Nitric Oxide
Nitric Oxide Synthase