Benzothienyloxy phenylpropanamines, novel dual inhibitors of serotonin and norepinephrine reuptake

Bioorg Med Chem Lett. 2004 Nov 1;14(21):5395-9. doi: 10.1016/j.bmcl.2004.08.005.

Abstract

A series of benzothienyloxy propylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.

MeSH terms

  • Adrenergic Uptake Inhibitors / chemical synthesis*
  • Adrenergic Uptake Inhibitors / pharmacology
  • Antidepressive Agents / chemical synthesis*
  • Antidepressive Agents / pharmacology
  • Dopamine Plasma Membrane Transport Proteins
  • Humans
  • In Vitro Techniques
  • Membrane Glycoproteins / metabolism
  • Membrane Transport Proteins / metabolism
  • Microsomes, Liver / metabolism
  • Nerve Tissue Proteins / metabolism
  • Norepinephrine / antagonists & inhibitors*
  • Norepinephrine / metabolism
  • Norepinephrine Plasma Membrane Transport Proteins
  • Propylamines / chemical synthesis*
  • Propylamines / pharmacology
  • Selective Serotonin Reuptake Inhibitors / chemical synthesis*
  • Selective Serotonin Reuptake Inhibitors / pharmacology
  • Serotonin Plasma Membrane Transport Proteins
  • Stereoisomerism
  • Structure-Activity Relationship
  • Symporters / metabolism
  • Thiophenes / chemical synthesis*
  • Thiophenes / pharmacology

Substances

  • Adrenergic Uptake Inhibitors
  • Antidepressive Agents
  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Norepinephrine Plasma Membrane Transport Proteins
  • Propylamines
  • SLC6A2 protein, human
  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin Uptake Inhibitors
  • Symporters
  • Thiophenes
  • Norepinephrine