Abstract
A series of benzothienyloxy propylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.
MeSH terms
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Adrenergic Uptake Inhibitors / chemical synthesis*
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Adrenergic Uptake Inhibitors / pharmacology
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Antidepressive Agents / chemical synthesis*
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Antidepressive Agents / pharmacology
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Dopamine Plasma Membrane Transport Proteins
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Humans
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In Vitro Techniques
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Membrane Glycoproteins / metabolism
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Membrane Transport Proteins / metabolism
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Microsomes, Liver / metabolism
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Nerve Tissue Proteins / metabolism
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Norepinephrine / antagonists & inhibitors*
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Norepinephrine / metabolism
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Norepinephrine Plasma Membrane Transport Proteins
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Propylamines / chemical synthesis*
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Propylamines / pharmacology
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Selective Serotonin Reuptake Inhibitors / chemical synthesis*
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Selective Serotonin Reuptake Inhibitors / pharmacology
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Serotonin Plasma Membrane Transport Proteins
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Stereoisomerism
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Structure-Activity Relationship
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Symporters / metabolism
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Thiophenes / chemical synthesis*
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Thiophenes / pharmacology
Substances
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Adrenergic Uptake Inhibitors
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Antidepressive Agents
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Dopamine Plasma Membrane Transport Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Norepinephrine Plasma Membrane Transport Proteins
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Propylamines
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SLC6A2 protein, human
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins
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Serotonin Uptake Inhibitors
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Symporters
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Thiophenes
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Norepinephrine