Modification of biological activity of lipopolysaccharide in the complex with chitosan

I M Ermak; V N Davydova; V I Gorbach; E L Berdyshev; T A Kuznetsova; I A Ivanushko; A K Gazha; T P Smolina; T S Zaporozhets; T F Solov'eva

doi:10.1023/b:bebm.0000035136.61014.c2

Modification of biological activity of lipopolysaccharide in the complex with chitosan

Bull Exp Biol Med. 2004 Apr;137(4):379-81. doi: 10.1023/b:bebm.0000035136.61014.c2.

Authors

I M Ermak¹, V N Davydova, V I Gorbach, E L Berdyshev, T A Kuznetsova, I A Ivanushko, A K Gazha, T P Smolina, T S Zaporozhets, T F Solov'eva

Affiliation

¹ Pacific Ocean Institute of Bioorganic Chemistry, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok. iren@piboc.dvo.ru

PMID: 15452608
DOI: 10.1023/b:bebm.0000035136.61014.c2

Abstract

In the complex with chitosan, lipopolysaccharide partially lost its ability to induce lymphokines tumor necrosis factor and interleukin-8, but retained immunostimulating properties and increased phagocytic function of macrophages by improving digestion of bacteria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chitosan / immunology*
Escherichia coli / metabolism
Interleukin-8 / immunology
Lipopolysaccharides / immunology*
Macromolecular Substances
Macrophages, Peritoneal / immunology
Mice
Spleen / cytology
Spleen / immunology
Tumor Necrosis Factor-alpha / immunology
Yersinia pseudotuberculosis / metabolism

Substances

Interleukin-8
Lipopolysaccharides
Macromolecular Substances
Tumor Necrosis Factor-alpha
Chitosan