Regulation of WASP/WAVE proteins: making a long story short

J Cell Biol. 2004 Sep 27;166(7):957-62. doi: 10.1083/jcb.200403127.

Abstract

Despite their homology, the regulation of WASP and WAVE, activators of Arp2/3-dependent actin polymerization, has always been thought to be different. Several recent studies have revealed new aspects of their regulation, highlighting its complexity and the crucial role of post-translational modifications. New data also suggest additional functions for WASP family proteins, pushing us to reconsider existing models.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin-Related Protein 2
  • Actins / genetics
  • Actins / metabolism*
  • Animals
  • Cytoskeletal Proteins / genetics
  • Cytoskeletal Proteins / metabolism
  • Humans
  • Macromolecular Substances
  • Microfilament Proteins / genetics
  • Microfilament Proteins / metabolism*
  • Models, Biological
  • Monomeric GTP-Binding Proteins / genetics
  • Monomeric GTP-Binding Proteins / metabolism
  • Protein Processing, Post-Translational / genetics
  • Proteins / genetics
  • Proteins / metabolism*
  • Signal Transduction / genetics
  • Wiskott-Aldrich Syndrome Protein
  • Wiskott-Aldrich Syndrome Protein Family

Substances

  • ACTR2 protein, human
  • Actin-Related Protein 2
  • Actins
  • Cytoskeletal Proteins
  • Macromolecular Substances
  • Microfilament Proteins
  • Proteins
  • WAS protein, human
  • Wiskott-Aldrich Syndrome Protein
  • Wiskott-Aldrich Syndrome Protein Family
  • Monomeric GTP-Binding Proteins