Abstract
Despite their homology, the regulation of WASP and WAVE, activators of Arp2/3-dependent actin polymerization, has always been thought to be different. Several recent studies have revealed new aspects of their regulation, highlighting its complexity and the crucial role of post-translational modifications. New data also suggest additional functions for WASP family proteins, pushing us to reconsider existing models.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Actin-Related Protein 2
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Actins / genetics
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Actins / metabolism*
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Animals
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Cytoskeletal Proteins / genetics
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Cytoskeletal Proteins / metabolism
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Humans
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Macromolecular Substances
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Microfilament Proteins / genetics
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Microfilament Proteins / metabolism*
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Models, Biological
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Monomeric GTP-Binding Proteins / genetics
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Monomeric GTP-Binding Proteins / metabolism
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Protein Processing, Post-Translational / genetics
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Proteins / genetics
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Proteins / metabolism*
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Signal Transduction / genetics
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Wiskott-Aldrich Syndrome Protein
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Wiskott-Aldrich Syndrome Protein Family
Substances
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ACTR2 protein, human
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Actin-Related Protein 2
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Actins
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Cytoskeletal Proteins
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Macromolecular Substances
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Microfilament Proteins
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Proteins
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WAS protein, human
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Wiskott-Aldrich Syndrome Protein
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Wiskott-Aldrich Syndrome Protein Family
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Monomeric GTP-Binding Proteins