Abstract
In guinea pig hippocampal slices, the GABA(B) receptor antagonist CGP 35348 increased the length of picrotoxin-induced interictal bursts by only 22%, yet it increased the length of group I mGluR-induced ictaform bursts by 85%. These data suggest that (1) suppression of GABAergic inhibition is insufficient to account for group I mGluR agonist-induced ictaform bursts, and (2) although GABA(B) plays a minor role in terminating interictal bursts, it is a major contributor to the termination of mGluR-induced ictaform bursts.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Convulsants / pharmacology
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Electroencephalography / drug effects
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Epilepsy / chemically induced
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Epilepsy / physiopathology
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GABA Antagonists / pharmacology
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Glycine / analogs & derivatives*
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Glycine / pharmacology
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Guinea Pigs
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In Vitro Techniques
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Membrane Potentials / drug effects
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Organophosphorus Compounds / pharmacology
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Picrotoxin / pharmacology
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Pyramidal Cells / drug effects
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Pyramidal Cells / physiology
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Receptors, GABA-B / drug effects
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Receptors, GABA-B / physiology*
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Receptors, Metabotropic Glutamate / agonists*
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Resorcinols / pharmacology
Substances
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Convulsants
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GABA Antagonists
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Organophosphorus Compounds
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Receptors, GABA-B
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Receptors, Metabotropic Glutamate
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Resorcinols
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metabotropic glutamate receptor type 1
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Picrotoxin
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3,5-dihydroxyphenylglycine
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CGP 35348
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Glycine