The paper presents the results of an examination of 269 patients (including 205 males and 64 females) aged 18-62 years who had gastroduodenal ulcers; amongst them, 137 and 132 patients were treated in the in- and out-patient settings, respectively. It was ascertained that the pathomorphism of the clinical picture of peptic ulcer had occurred. About a third of all the exacerbations became asymptomatic or displayed few symptoms. In patients with duodenal ulcer, the epigastrium rather than the right hypochondrium is the most common site of pain on an exacerbation.