Insertion of spliceosomal introns in proto-splice sites: the case of secretory signal peptides

Hedvig Tordai; László Patthy

doi:10.1016/j.febslet.2004.08.045

Insertion of spliceosomal introns in proto-splice sites: the case of secretory signal peptides

FEBS Lett. 2004 Sep 24;575(1-3):109-11. doi: 10.1016/j.febslet.2004.08.045.

Authors

Hedvig Tordai¹, László Patthy

Affiliation

¹ Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Karolina út 29, P.O. Box 7, Budapest H-1518, Hungary.

PMID: 15388343
DOI: 10.1016/j.febslet.2004.08.045

Abstract

Analysis of the exon-intron structures of 2208 human genes has revealed that there is a statistically highly significant excess of phase 1 introns in the vicinity of the signal peptide cleavage sites. It is suggested that amino acid sequences surrounding signal peptide cleavage sites are significantly enriched in phase 1 proto-splice sites and this has favored insertion of spliceosomal introns in these sites.

MeSH terms

Amino Acid Sequence
Animals
Humans
Introns*
Molecular Sequence Data
Protein Sorting Signals* / genetics
RNA Splice Sites*
RNA Splicing
Spliceosomes / genetics*
Spliceosomes / metabolism

Substances

Protein Sorting Signals
RNA Splice Sites