Abstract
In this paper, we describe the preparation of human serum albumin-coated magnetic particles of about 200 nm in diameter with narrow size distribution radiolabeled with 188Re for the purpose of magnetically targeted therapy. The optimum radiolabeling conditions are: SnCl2 x 2H2O 8 mg/ml, citric acid 20 mg/ml, vitamin C 8 mg/ml, labeling volume 500 microl and a reaction time of 3 h. The stability of the radiolabeled particles is suitable for in vivo study.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adsorption
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Coated Materials, Biocompatible / chemical synthesis
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Coated Materials, Biocompatible / chemistry*
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Drug Carriers / chemical synthesis
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Drug Carriers / chemistry*
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Drug Stability
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Ferrosoferric Oxide
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Iron / chemistry*
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Isotope Labeling / methods
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Nanotubes / chemistry*
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Nanotubes / ultrastructure
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Oxides / chemistry*
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Particle Size
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Pest Control, Biological
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Radioisotopes / administration & dosage*
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Radioisotopes / chemistry*
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Radiotherapy / methods
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Rhenium
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Serum Albumin / chemistry*
Substances
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Coated Materials, Biocompatible
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Drug Carriers
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Oxides
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Radioisotopes
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Serum Albumin
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Rhenium
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Iron
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Ferrosoferric Oxide