Preparation and radiolabeling of human serum albumin (HSA)-coated magnetite nanoparticles for magnetically targeted therapy

Appl Radiat Isot. 2004 Dec;61(6):1255-9. doi: 10.1016/j.apradiso.2004.03.114.

Abstract

In this paper, we describe the preparation of human serum albumin-coated magnetic particles of about 200 nm in diameter with narrow size distribution radiolabeled with 188Re for the purpose of magnetically targeted therapy. The optimum radiolabeling conditions are: SnCl2 x 2H2O 8 mg/ml, citric acid 20 mg/ml, vitamin C 8 mg/ml, labeling volume 500 microl and a reaction time of 3 h. The stability of the radiolabeled particles is suitable for in vivo study.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Coated Materials, Biocompatible / chemical synthesis
  • Coated Materials, Biocompatible / chemistry*
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry*
  • Drug Stability
  • Ferrosoferric Oxide
  • Iron / chemistry*
  • Isotope Labeling / methods
  • Nanotubes / chemistry*
  • Nanotubes / ultrastructure
  • Oxides / chemistry*
  • Particle Size
  • Pest Control, Biological
  • Radioisotopes / administration & dosage*
  • Radioisotopes / chemistry*
  • Radiotherapy / methods
  • Rhenium
  • Serum Albumin / chemistry*

Substances

  • Coated Materials, Biocompatible
  • Drug Carriers
  • Oxides
  • Radioisotopes
  • Serum Albumin
  • Rhenium
  • Iron
  • Ferrosoferric Oxide