Abstract
A short preparation of polyoxygenated macrocycles can be carried out by combining the formation of an acetal linkage, to introduce long alkyl chains, with a ring closure metathesis. As an example, this methodology was used to synthesize a new polyamino lipid.
Copyright 2004 American Chemical Society
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetals / chemistry*
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Genetic Vectors / chemical synthesis
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Lipids / chemical synthesis*
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Macrocyclic Compounds / chemistry*
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Models, Chemical
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Molecular Structure
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Polyamines / chemical synthesis*
Substances
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Acetals
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Lipids
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Macrocyclic Compounds
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Polyamines