Short synthesis of polyoxygenated macrocyclic rings using acetal linkages. Application to the preparation of a new lipidic polyamine

J Org Chem. 2004 Oct 1;69(20):6949-52. doi: 10.1021/jo0493020.

Abstract

A short preparation of polyoxygenated macrocycles can be carried out by combining the formation of an acetal linkage, to introduce long alkyl chains, with a ring closure metathesis. As an example, this methodology was used to synthesize a new polyamino lipid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetals / chemistry*
  • Genetic Vectors / chemical synthesis
  • Lipids / chemical synthesis*
  • Macrocyclic Compounds / chemistry*
  • Models, Chemical
  • Molecular Structure
  • Polyamines / chemical synthesis*

Substances

  • Acetals
  • Lipids
  • Macrocyclic Compounds
  • Polyamines