Abstract
Objective:
Fluoxetine, a selective serotonin reuptake inhibitor antidepressant agent, has been implicated in learning and memory. Here, we report four cases from the same family of fluoxetine-related memory-impairment.
Results:
Memory-impairment resulted after fluoxetine treatment and disappeared after changing to another selective serotonin reuptake inhibitor.
Conclusions:
There may be a relationship between fluoxetine-related memory impairment and genetic factors, and this side-effect appears to be specific to fluoxetine treatment. Possible mechanisms underlying this effect may be the drug's influence on the central serotonergic system or brain-derived neurotrophic factor.
MeSH terms
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Adult
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Antidepressive Agents, Second-Generation / administration & dosage
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Antidepressive Agents, Second-Generation / adverse effects*
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Depressive Disorder / diagnosis
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Depressive Disorder / drug therapy*
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Depressive Disorder / genetics
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Depressive Disorder, Major / diagnosis
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Depressive Disorder, Major / drug therapy
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Depressive Disorder, Major / genetics
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Female
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Fluoxetine / administration & dosage
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Fluoxetine / adverse effects*
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Genetic Predisposition to Disease / genetics
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Humans
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Memory Disorders / chemically induced*
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Memory Disorders / diagnosis
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Memory Disorders / genetics
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Phenotype
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Selective Serotonin Reuptake Inhibitors / adverse effects*
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Selective Serotonin Reuptake Inhibitors / therapeutic use
Substances
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Antidepressive Agents, Second-Generation
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Serotonin Uptake Inhibitors
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Fluoxetine