Fluoxetine-induced memory impairment in four family members

Int J Psychiatry Med. 2004;34(2):197-200. doi: 10.2190/DY6D-33BP-5WPB-1VDX.

Abstract

Objective: Fluoxetine, a selective serotonin reuptake inhibitor antidepressant agent, has been implicated in learning and memory. Here, we report four cases from the same family of fluoxetine-related memory-impairment.

Results: Memory-impairment resulted after fluoxetine treatment and disappeared after changing to another selective serotonin reuptake inhibitor.

Conclusions: There may be a relationship between fluoxetine-related memory impairment and genetic factors, and this side-effect appears to be specific to fluoxetine treatment. Possible mechanisms underlying this effect may be the drug's influence on the central serotonergic system or brain-derived neurotrophic factor.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antidepressive Agents, Second-Generation / administration & dosage
  • Antidepressive Agents, Second-Generation / adverse effects*
  • Depressive Disorder / diagnosis
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / genetics
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / drug therapy
  • Depressive Disorder, Major / genetics
  • Female
  • Fluoxetine / administration & dosage
  • Fluoxetine / adverse effects*
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Memory Disorders / chemically induced*
  • Memory Disorders / diagnosis
  • Memory Disorders / genetics
  • Phenotype
  • Selective Serotonin Reuptake Inhibitors / adverse effects*
  • Selective Serotonin Reuptake Inhibitors / therapeutic use

Substances

  • Antidepressive Agents, Second-Generation
  • Serotonin Uptake Inhibitors
  • Fluoxetine