Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice

Chikara Nakasone; Kazuyoshi Kawakami; Tomoaki Hoshino; Yusuke Kawase; Koichi Yokota; Kohichiro Yoshino; Kiyoshi Takeda; Shizuo Akira; Atsushi Saito

doi:10.1128/IAI.72.10.6176-6180.2003

Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice

Infect Immun. 2004 Oct;72(10):6176-80. doi: 10.1128/IAI.72.10.6176-6180.2003.

Authors

Chikara Nakasone¹, Kazuyoshi Kawakami, Tomoaki Hoshino, Yusuke Kawase, Koichi Yokota, Kohichiro Yoshino, Kiyoshi Takeda, Shizuo Akira, Atsushi Saito

Affiliation

¹ Department of Internal Medicine, Division of Infectious Diseases, Graduate School and Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.

Abstract

We report that clearance of Pseudomonas aeruginosa, accumulation of neutrophils, and synthesis of tumor necrosis factor alpha and macrophage inflammatory protein 2 in the infected lung were not largely different in interleukin-18 (IL-18) knockout or transgenic mice compared with control mice. Our results suggest a limited role for IL-18 in the host defense against P. aeruginosa.

MeSH terms

Animals
Chemokine CXCL2
Gene Deletion*
Interleukin-18 / deficiency
Interleukin-18 / genetics*
Interleukin-18 / physiology*
Lung / immunology
Lung / metabolism
Lung / microbiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Monokines / biosynthesis
Monokines / immunology
Neutrophils / immunology
Neutrophils / metabolism
Pseudomonas Infections / immunology*
Pseudomonas Infections / metabolism
Pseudomonas Infections / prevention & control
Pseudomonas aeruginosa / immunology*
Tumor Necrosis Factor-alpha / biosynthesis
Tumor Necrosis Factor-alpha / immunology

Substances

Chemokine CXCL2
Interleukin-18
Monokines
Tumor Necrosis Factor-alpha