Abstract
A fusion protein of antigen 85B (Ag85B) and ESAT-6 administered in cationic lipid vesicles conferred a highly significant level of protection against Mycobacterium tuberculosis in the guinea pig aerosol model of infection. The protection was manifested as delayed clinical illness and prolonged survival. Neither Ag85B nor ESAT-6 (independently or as a cocktail) induced significant protection in this model.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyltransferases / genetics
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Acyltransferases / immunology*
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Aerosols
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Animals
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Antigens, Bacterial / genetics
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Antigens, Bacterial / immunology*
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Bacterial Proteins / genetics
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Bacterial Proteins / immunology*
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Guinea Pigs
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Hypersensitivity, Delayed / immunology
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Liposomes / administration & dosage
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / immunology*
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / immunology
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Skin Tests
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Survival Rate
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Time Factors
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Tuberculosis / immunology*
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Tuberculosis / prevention & control
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Tuberculosis Vaccines / administration & dosage
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Tuberculosis Vaccines / genetics
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Tuberculosis Vaccines / immunology*
Substances
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Aerosols
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Antigens, Bacterial
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Bacterial Proteins
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ESAT-6 protein, Mycobacterium tuberculosis
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Liposomes
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Recombinant Fusion Proteins
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Tuberculosis Vaccines
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Acyltransferases
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antigen 85B, Mycobacterium tuberculosis