Abstract
Poly(methyl methacrylate), PMMA, and of PMMA/Poly(epsilon-caprolactone), PCL, microspheres were loaded with different amounts of cholesterol by using a supercritical carbon dioxide (SC-CO2) impregnation process in order to use a clean technique with the absence of organic solvents, and to provide information for the infusion of additives into nonporous polymeric substrates. A conventional dissolution-evaporation method was also used to obtain PMMA and PMMA-PCL microparticles loaded with cholesterol. The obtained microspheres were characterized by environmental scanning electronic microscope, ESEM, nuclear magnetic resonance spectroscopy, NMR, and differential scanning calorimetry, DSC, thermal analysis. A comparison of drug release from particles obtained using both methods, the supercritical and the conventional, is presented.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Calorimetry, Differential Scanning / methods
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Carbon Dioxide / chemistry
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Carbon Dioxide / pharmacokinetics*
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Chemistry, Pharmaceutical / instrumentation
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Chemistry, Pharmaceutical / methods
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Cholesterol / chemistry*
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Cholesterol / pharmacokinetics
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Drug Delivery Systems / methods*
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Drug Delivery Systems / trends
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Evaluation Studies as Topic
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Excipients / chemistry
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Excipients / pharmacokinetics
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Magnetic Resonance Spectroscopy / methods
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Microscopy, Electron, Scanning / methods
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Microspheres*
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Particle Size
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Polyesters / chemistry*
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Polyesters / pharmacokinetics
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Polymethyl Methacrylate / chemistry*
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Polymethyl Methacrylate / pharmacokinetics
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Solubility
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Solutions / chemistry
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Solutions / pharmacokinetics
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Spain
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Technology, Pharmaceutical / instrumentation
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Technology, Pharmaceutical / methods
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Thermodynamics
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Volatilization
Substances
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Excipients
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Polyesters
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Solutions
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Carbon Dioxide
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polycaprolactone
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Polymethyl Methacrylate
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Cholesterol