Abstract
The present study was aimed at investigating whether two-kidney, one clip (2K1C) hypertension is associated with an enhanced central adrenergic activity. Rats were made 2K1C hypertensive, and the expression of Fos-like immunoreactivity (FLI) and phenylethanalamine N-methyltransferase (PNMT)-immunoreactivity was determined in the brain areas related to the cardiovascular regulation. In 2K1C hypertension, the basal Fos-immunoreactivity was significantly increased in rostral ventrolateral medulla (RVLM), paraventricular nucleus (PVN), and supraoptic nucleus (SON). PNMT-immunoreactivities were noted in RVLM, but not in PVN or SON. Intracerebroventricular administration of angiotensin II (AII) markedly increased Fos-immunoreactivities, the degree of which was greater in hypertension. Furthermore, AII increased the ratio of PNMT-positive/Fos-positive neurons in RVLM in hypertension. It is suggested that the responsiveness to AII of the central adrenergic system is enhanced in 2K1C hypertension.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiotensin II / pharmacology
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Animals
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Antihypertensive Agents / administration & dosage
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Antihypertensive Agents / therapeutic use
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Blood Pressure / drug effects
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Blood Pressure / physiology
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Brain / cytology*
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Brain / drug effects
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Brain / metabolism
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Cell Count / methods
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Disease Models, Animal
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Heart Rate / drug effects
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Heart Rate / physiology
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Hypertension, Renovascular / drug therapy
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Hypertension, Renovascular / etiology
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Hypertension, Renovascular / metabolism*
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Hypertension, Renovascular / physiopathology
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Immunohistochemistry / methods
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Male
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Neurons / drug effects
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Neurons / metabolism*
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Nitroprusside / administration & dosage
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Nitroprusside / therapeutic use
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Phenylethanolamine N-Methyltransferase / metabolism
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Proto-Oncogene Proteins c-fos / metabolism
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Rats
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Rats, Sprague-Dawley
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Receptors, Adrenergic / metabolism*
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Renal Artery Obstruction / complications
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Renal Artery Obstruction / drug therapy
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Renal Artery Obstruction / metabolism*
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Renal Artery Obstruction / physiopathology
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Vasoconstrictor Agents / pharmacology
Substances
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Antihypertensive Agents
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Proto-Oncogene Proteins c-fos
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Receptors, Adrenergic
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Vasoconstrictor Agents
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Angiotensin II
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Nitroprusside
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Phenylethanolamine N-Methyltransferase