Biaryl guanidine inhibitors of in vitro HCV-IRES activity

Bioorg Med Chem Lett. 2004 Oct 18;14(20):5139-43. doi: 10.1016/j.bmcl.2004.07.066.

Abstract

A structure-activity relationship analysis was carried out on a high-throughput small molecule screening lead for HCV-IRES translation inhibition. The study led to the identification of a guanidine-based structure with low microM inhibitory activity.

Publication types

  • Comparative Study

MeSH terms

  • Antiviral Agents / chemistry*
  • Antiviral Agents / pharmacology
  • Databases, Factual
  • Guanidines / chemistry*
  • Hepacivirus / genetics*
  • Hepacivirus / metabolism
  • Protein Biosynthesis / drug effects*
  • Ribosomes / drug effects
  • Ribosomes / genetics
  • Structure-Activity Relationship
  • Transcription, Genetic / drug effects
  • Viral Proteins / antagonists & inhibitors*
  • Viral Proteins / biosynthesis

Substances

  • Antiviral Agents
  • Guanidines
  • Viral Proteins