MPTP as a mitochondrial neurotoxic model of Parkinson's disease

J Bioenerg Biomembr. 2004 Aug;36(4):375-9. doi: 10.1023/B:JOBB.0000041771.66775.d5.

Abstract

1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent neurotoxin extensively used to model Parkinson's disease (PD). A cascade of deleterous events, in which mitochondria play a pivotal role, drives MPTP neurotoxicity. How mitochondria are affected by MPTP and how their defect contributes to the demise of dopaminergic neurons in this model of PD are discussed in this review.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / administration & dosage*
  • Adenosine Triphosphate / metabolism
  • Animals
  • Apoptosis / drug effects
  • Disease Models, Animal
  • MPTP Poisoning / chemically induced*
  • MPTP Poisoning / metabolism*
  • Mice
  • Mitochondria / drug effects*
  • Mitochondria / metabolism*
  • Mitochondrial Diseases / chemically induced
  • Mitochondrial Diseases / metabolism
  • Mitochondrial Proteins / metabolism
  • Neurons / drug effects*
  • Neurons / metabolism*
  • Neurotoxins / toxicity
  • Rats
  • Reactive Oxygen Species / metabolism

Substances

  • Mitochondrial Proteins
  • Neurotoxins
  • Reactive Oxygen Species
  • Adenosine Triphosphate
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine