Plasma homocysteine levels after hormone therapy with and without folic acid supplementation: a randomized study

Fabio Ghezzi; Marco Buttarelli; Antonella Cromi; Luigi Raio; Marcelle Cedars; Pierfrancesco Bolis

doi:10.1016/j.fertnstert.2004.01.046

Plasma homocysteine levels after hormone therapy with and without folic acid supplementation: a randomized study

Fertil Steril. 2004 Sep;82(3):746-8. doi: 10.1016/j.fertnstert.2004.01.046.

Authors

Fabio Ghezzi¹, Marco Buttarelli, Antonella Cromi, Luigi Raio, Marcelle Cedars, Pierfrancesco Bolis

Affiliation

¹ Department of Obstetrics and Gynecology, University of Insubria, Del Ponte Hospital, Piazza Biroldi 1, 21100 Varese, Italy. fabio.ghezzi@uninsubria.it

PMID: 15374727
DOI: 10.1016/j.fertnstert.2004.01.046

Abstract

Sequential transdermal estrogen-progestin therapy induced a significant reduction in fasting serum homocysteine levels in postmenopausal women. The addition of folic acid supplementation for 6 months did not further lower the homocysteine concentrations.

Publication types

Clinical Trial
Comparative Study
Randomized Controlled Trial

MeSH terms

Adult
Dietary Supplements
Estradiol / therapeutic use
Estrogen Replacement Therapy*
Female
Folic Acid / therapeutic use*
Homocysteine / blood*
Humans
Middle Aged
Postmenopause / drug effects
Postmenopause / physiology*

Substances

Homocysteine
Estradiol
Folic Acid