Effect of transfer of human ApoA1 gene on development of dyslipoproteinemias in rats: Age peculiarities

V V Frolkis; V A Kordjum; L N Bogatskaya; S N Novikova; V N Shulzhenko; I E Kostetsky; T G Mozzhukhina; R I Potapenko; V E Sabko; G I Paramonova; A L Shkapenko

doi:10.1016/0167-4943(91)90044-q

Effect of transfer of human ApoA1 gene on development of dyslipoproteinemias in rats: Age peculiarities

Arch Gerontol Geriatr. 1991 Nov-Dec;13(3):225-35. doi: 10.1016/0167-4943(91)90044-q.

Authors

V V Frolkis¹, V A Kordjum, L N Bogatskaya, S N Novikova, V N Shulzhenko, I E Kostetsky, T G Mozzhukhina, R I Potapenko, V E Sabko, G I Paramonova, A L Shkapenko

Affiliation

¹ Institute of Gerontology, AMS U.S.S.R., Kiev and Institute of Molecular Biology and Genetics, AS Ukr. S.S.R., Kiev, U.S.S.R.

PMID: 15374415
DOI: 10.1016/0167-4943(91)90044-q

Abstract

Transfer of human ApoA1 gene within the molecular construction which provides its expression, to the liver of the adult and aged rats resulted in the appearance of human protein in their blood, and was accompanied by changes in the content of high-density lipoproteins and of their subclasses HDL(3) and HDL(2), as well as by the shifts in their protein and lipid composition. Synthesis of human ApoA1 was more marked in the organism of adult rats, and gene-regulatory shifts in aged rats.