Function of the lipopolysaccharide-binding protein of Periplaneta americana as an opsonin

FEBS Lett. 1992 Jan 27;296(3):283-6. doi: 10.1016/0014-5793(92)80305-z.

Abstract

Previously, we reported the purification of an LPS-binding protein from the hemolymph of the American cockroach that was specific for E. coli LPS. In this study we found that this protein participated in the clearance of E. coli cells injected into the abdominal cavity of the cockroach, and that hemocytes ingested E. coli cells treated with this LPS-binding protein in vitro. These findings suggest that this LPS-binding protein acts as an opsonin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute-Phase Proteins*
  • Animals
  • Antibodies / metabolism
  • Carrier Proteins / physiology*
  • Escherichia coli / immunology
  • Hemocytes / metabolism
  • Kinetics
  • Membrane Glycoproteins*
  • Opsonin Proteins / physiology*
  • Periplaneta / immunology*

Substances

  • Acute-Phase Proteins
  • Antibodies
  • Carrier Proteins
  • Membrane Glycoproteins
  • Opsonin Proteins
  • lipopolysaccharide-binding protein