Pantoprazole-induced acute interstitial nephritis

J Nephrol. 2004 Jul-Aug;17(4):580-1.

Abstract

Pantoprazole is a proton-pump inhibitor (PPI) that is commonly prescribed for the treatment of gastroesophageal reflux-related disorders. There are many documented side effects of PPIs. Here we report a case of acute interstitial nephritis, which developed after 6 weeks of treatment with pantoprazole. A 23-year-old man presented with acute renal failure requiring renal replacement therapy. Acute interstitial nephritis was diagnosed by renal biopsy and was successfully treated with corticosteroids and withdrawal of pantoprazole. Drug-induced acute interstitial nephritis can occur with PPIs such as pantoprazole and vigilance needs to be maintained.

Publication types

  • Case Reports

MeSH terms

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Adult
  • Benzimidazoles / adverse effects*
  • Benzimidazoles / therapeutic use
  • Biopsy, Needle
  • Drug Hypersensitivity / diagnosis
  • Drug Hypersensitivity / etiology*
  • Follow-Up Studies
  • Gastroesophageal Reflux / diagnosis
  • Gastroesophageal Reflux / drug therapy
  • Humans
  • Immunohistochemistry
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Nephritis, Interstitial / chemically induced*
  • Nephritis, Interstitial / drug therapy
  • Nephritis, Interstitial / pathology
  • Omeprazole / adverse effects*
  • Omeprazole / analogs & derivatives*
  • Omeprazole / therapeutic use
  • Pantoprazole
  • Risk Assessment
  • Sulfoxides / adverse effects*
  • Sulfoxides / therapeutic use
  • Treatment Outcome

Substances

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Benzimidazoles
  • Immunosuppressive Agents
  • Sulfoxides
  • Pantoprazole
  • Omeprazole