Analytical correlation between plasma N-terminal pro-brain natriuretic peptide and brain natriuretic peptide in patients presenting with dyspnea

Clin Biochem. 2004 Oct;37(10):933-6. doi: 10.1016/j.clinbiochem.2004.06.009.

Abstract

Objectives: We examined the analytical correlation N-terminal pro-brain natriuretic peptide (NT-proBNP) and brain natriuretic peptide (BNP).

Design and methods: Electrochemiluminescence and fluorescence immunoassays were used to measure NT-proBNP and BNP levels, respectively.

Results: The analytical correlation was satisfactory using the equation: NT-proBNP = 8.56 x BNP + 91.7 and a correlation r = 0.85. The correlation was not influenced by age, gender and BMI of patients.

Conclusions: We conclude that NT-proBNP correlates with BNP.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Dyspnea / blood
  • Dyspnea / diagnosis*
  • Electrochemistry
  • Female
  • Fluorescence
  • Humans
  • Immunoassay
  • Luminescent Measurements
  • Male
  • Natriuretic Peptide, Brain / blood*
  • Nerve Tissue Proteins / blood*
  • Peptide Fragments / blood*
  • Prognosis
  • Reproducibility of Results
  • Sensitivity and Specificity

Substances

  • Nerve Tissue Proteins
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain