Abstract
Ischemic stroke is a devastating neurological disease. The responsible mechanisms are not completely understood. In this issue of Cell, Xiong et al. (2004) elucidate a molecular mechanism by which acidosis damages the brain during ischemia.
MeSH terms
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Acidosis / etiology*
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Acidosis / metabolism
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Acidosis / physiopathology*
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Animals
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Brain Ischemia / drug therapy
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Brain Ischemia / metabolism
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Brain Ischemia / physiopathology*
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Excitatory Amino Acid Antagonists / pharmacology
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Excitatory Amino Acid Antagonists / therapeutic use
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Glutamic Acid / metabolism
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Glutamic Acid / toxicity
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Humans
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Nerve Degeneration / drug therapy
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Nerve Degeneration / etiology
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Nerve Degeneration / physiopathology
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Neuroprotective Agents / pharmacology
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Neuroprotective Agents / therapeutic use
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Receptors, Glutamate / drug effects
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Receptors, Glutamate / metabolism
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Stroke / drug therapy
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Stroke / metabolism
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Stroke / physiopathology*
Substances
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Excitatory Amino Acid Antagonists
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Neuroprotective Agents
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Receptors, Glutamate
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Glutamic Acid