Ischemic stroke: "acidotoxicity" is a perpetrator

Cell. 2004 Sep 17;118(6):665-6. doi: 10.1016/j.cell.2004.09.004.

Abstract

Ischemic stroke is a devastating neurological disease. The responsible mechanisms are not completely understood. In this issue of Cell, Xiong et al. (2004) elucidate a molecular mechanism by which acidosis damages the brain during ischemia.

Publication types

  • Comment
  • Review

MeSH terms

  • Acidosis / etiology*
  • Acidosis / metabolism
  • Acidosis / physiopathology*
  • Animals
  • Brain Ischemia / drug therapy
  • Brain Ischemia / metabolism
  • Brain Ischemia / physiopathology*
  • Excitatory Amino Acid Antagonists / pharmacology
  • Excitatory Amino Acid Antagonists / therapeutic use
  • Glutamic Acid / metabolism
  • Glutamic Acid / toxicity
  • Humans
  • Nerve Degeneration / drug therapy
  • Nerve Degeneration / etiology
  • Nerve Degeneration / physiopathology
  • Neuroprotective Agents / pharmacology
  • Neuroprotective Agents / therapeutic use
  • Receptors, Glutamate / drug effects
  • Receptors, Glutamate / metabolism
  • Stroke / drug therapy
  • Stroke / metabolism
  • Stroke / physiopathology*

Substances

  • Excitatory Amino Acid Antagonists
  • Neuroprotective Agents
  • Receptors, Glutamate
  • Glutamic Acid