Lack of increased left main coronary artery dimensions in hypertensive patients with left ventricular hypertrophy and coronary artery disease. An intracoronary ultrasound study

Acta Cardiol. 2004 Aug;59(4):397-403. doi: 10.2143/AC.59.4.2005205.

Abstract

Objectives: Left main coronary artery dimensions were evaluated in patients with and without arterial hypertension, in the presence of coronary artery disease, and correlated to left ventricular mass.

Methods and results: Intracoronary ultrasound was performed in 25 patients (pts) with coronary artery disease and hypertension (+HTN) and in 25 pts with coronary artery disease only (-HTN). Maximal left main dimensions and left ventricular mass index (LVMI) were measured. +HTN pts had greater LVMI compared to -HTN, (+HTN = 183 +/- 17 g/m2 vs. -HTN = 82 +/- 22 g/m2, p < 0.0001), while maximal left main vessel area was similar (25.99 +/- 5.01 mm2 vs. 25.62 +/- 3.3 mm2, p = 0.8). No correlation was found between LVMI and left main vessel area in + HTN.

Conclusions: Pts with +HTN despite the increased LVMI do not manifest increased LM dimensions. This may affect mid-term clinical outcome.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use
  • Aged
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Arteries / diagnostic imaging*
  • Arteries / pathology*
  • Blood Pressure / drug effects
  • Calcium Channel Blockers / therapeutic use
  • Coronary Angiography
  • Coronary Artery Disease / diagnosis*
  • Coronary Artery Disease / drug therapy
  • Coronary Artery Disease / epidemiology
  • Coronary Vessels / diagnostic imaging*
  • Coronary Vessels / pathology*
  • Diastole / drug effects
  • Female
  • Follow-Up Studies
  • Humans
  • Hypertension / diagnosis*
  • Hypertension / drug therapy
  • Hypertension / physiopathology
  • Hypertrophy, Left Ventricular / diagnosis*
  • Hypertrophy, Left Ventricular / drug therapy
  • Hypertrophy, Left Ventricular / epidemiology
  • Male
  • Middle Aged
  • Nitroglycerin / therapeutic use
  • Observer Variation
  • Statistics as Topic
  • Systole / drug effects
  • Treatment Outcome
  • Tunica Intima / diagnostic imaging
  • Tunica Intima / pathology
  • Ultrasonography, Interventional*
  • Vasodilator Agents / therapeutic use

Substances

  • Adrenergic beta-Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Calcium Channel Blockers
  • Vasodilator Agents
  • Nitroglycerin