Endocannabinoids: losing inhibition to increase learning capacity?

Stephen M Fitzjohn; Graham L Collingridge

doi:10.1016/j.neuron.2004.09.004

Endocannabinoids: losing inhibition to increase learning capacity?

Neuron. 2004 Sep 16;43(6):762-4. doi: 10.1016/j.neuron.2004.09.004.

Authors

Stephen M Fitzjohn¹, Graham L Collingridge

Affiliation

¹ MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, United Kingdom.

PMID: 15363388
DOI: 10.1016/j.neuron.2004.09.004

Abstract

Recent work has implicated endocannabinoids in various forms of synaptic plasticity. In this issue of Neuron, Chevaleyre and Castillo describe a new mechanism whereby a CB1 receptor-mediated LTD of inhibitory synaptic transmission facilitates the subsequent induction of LTP in a narrow band of synapses surrounding a region of potentiated synapses.

Publication types

Comment

MeSH terms

Animals
Cannabinoid Receptor Modulators / physiology*
Endocannabinoids*
In Vitro Techniques
Learning / physiology*
Mice
Neural Inhibition / physiology*
Neuronal Plasticity / physiology*
Synapses / physiology
Synaptic Transmission / physiology

Substances

Cannabinoid Receptor Modulators
Endocannabinoids