Abstract
It is becoming increasingly clear that parasitic protozoa remain a scourge to humans in the 21st century. The trypanosomes are a diverse group of insect-transmitted parasites that wiggle their way through multiple life cycle stages as they destroy human lives. Exquisitely detailed studies of these organisms reveal basic differences in gene expression that separate these single celled eukaryotes from multicellular eukaryotic organisms and have suggested numerous potential drug targets.
MeSH terms
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Animals
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DNA-Directed RNA Polymerases / metabolism
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Gene Expression Regulation*
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Genes, Protozoan
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Genetic Variation
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Models, Molecular
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Promoter Regions, Genetic
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Protozoan Proteins / biosynthesis*
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Protozoan Proteins / genetics*
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RNA / biosynthesis
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RNA, Messenger / metabolism
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Transcription, Genetic
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Trypanosoma / enzymology
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Trypanosoma / genetics*
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Trypanosoma / metabolism*
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Variant Surface Glycoproteins, Trypanosoma / genetics
Substances
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Protozoan Proteins
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RNA, Messenger
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Variant Surface Glycoproteins, Trypanosoma
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RNA
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DNA-Directed RNA Polymerases