Chip electrochromatography

J Chromatogr A. 2004 Jul 30;1044(1-2):97-111. doi: 10.1016/j.chroma.2004.04.075.

Abstract

Electrochromatography (EC) in microfluidic chips is emerging as an attractive alternative to capillary electrophoresis (CE) for on-chip separations. This review summarizes recent developments in the rapidly growing area of chip electrochromatography with a focus on "column" technologies. Relevant achievements are summarized according to the types of stationary phase used for the separations including open channels, microfabricated structures, and channels packed with beads or containing a porous monolith. The advantages and disadvantages of each, as well as practical aspects of their application, are discussed. The analytical performance of these devices is demonstrated with separations involving various families of compounds mostly in the reversed-phase chromatographic mode.

Publication types

  • Review

MeSH terms

  • Animals
  • Cattle
  • Chromatography, Micellar Electrokinetic Capillary / instrumentation*
  • Mass Spectrometry
  • Microscopy, Electron, Scanning
  • Polymers / chemistry

Substances

  • Polymers