1-[4-(Methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole derivatives

Caroline Charlier; Bernadette Norberg; Laurence Goossens; Jean Pierre Hénichart; François Durant

doi:10.1107/S0108270104016117

1-[4-(Methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole derivatives

Acta Crystallogr C. 2004 Sep;60(Pt 9):o648-52. doi: 10.1107/S0108270104016117. Epub 2004 Aug 11.

Authors

Caroline Charlier¹, Bernadette Norberg, Laurence Goossens, Jean Pierre Hénichart, François Durant

Affiliation

¹ Lab. Chimie Moléculaire Structurale, Facultés Universitaires N.-D. de la Paix, 61 Rue de Bruxelles, B-5000 Namur, Belgium. caroline.charlier@fundp.ac.be

PMID: 15345845
DOI: 10.1107/S0108270104016117

Abstract

Three related compounds containing a pyrazole moiety with vicinal phenyl rings featuring a methylsulfonyl substituent are described, namely 3-methyl-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole, C17H16N2O2S, ethyl 1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole-3-carboxylate, C19H18N2O4S, and 1-[4-(methylsulfonyl)phenyl]-3-[3-(morpholino)phenoxymethyl]-5-phenyl-1H-pyrazole, C27H27N3O4S. The design of these compounds was based on celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, in order to study the influence of various substituents on COX-2 and 5-lipoxygenase (5-LOX) inhibition.