The aim of this work is to determine the technical and economic feasibility of implementing different reclamation and reuse projects that improve the quality of the Apatlaco river basin located in the central part of Mexico. A special methodology based on a decision support system was developed. This methodology allows to decide if it is convenient or not to finance a reclamation or reuse project for the most common water uses in the basin. This methodology is based on the net present value criteria (NPV) of the effective cash flow during the useful life of the project. The results obtained reveal a technical and economical feasibility for industrial reuse in Jiutepec and for agricultural reuse in Zacatepec and Emiliano Zapata. On the other hand, sanitation projects are not feasible in all cases analyzed. Therefore, Mexican Regulation (Ley Federal de Derechos en Materia de Agua) as currently implemented, does not promote and support this kind of projects.