Effect of chronic heart failure on nuclear factor kappa B in peripheral leukocytes

Am J Cardiol. 2004 Sep 1;94(5):671-3. doi: 10.1016/j.amjcard.2004.05.041.

Abstract

Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor activated by various stimuli that are implicated in the progression of chronic heart failure. Therefore, we examined the activation of NF-kappaB in peripheral leukocytes, the only nucleated cell population noninvasively accessible in patients with heart failure. In patients with stable heart failure with no obvious other reason for NF-kappaB activation, NF-kappaB was significantly activated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Chronic Disease
  • Female
  • Heart Failure / blood
  • Heart Failure / metabolism*
  • Humans
  • Leukocytes / metabolism*
  • Male
  • Middle Aged
  • NF-kappa B / biosynthesis*
  • NF-kappa B / blood

Substances

  • NF-kappa B