Synthesis and evaluation of novel oxazoline MMP inhibitors

Gregory R Cook; Ethirajan Manivannan; Thane Underdahl; Viera Lukacova; Yufen Zhang; Stefan Balaz

doi:10.1016/j.bmcl.2004.07.023

Synthesis and evaluation of novel oxazoline MMP inhibitors

Bioorg Med Chem Lett. 2004 Oct 4;14(19):4935-9. doi: 10.1016/j.bmcl.2004.07.023.

Authors

Gregory R Cook¹, Ethirajan Manivannan, Thane Underdahl, Viera Lukacova, Yufen Zhang, Stefan Balaz

Affiliation

¹ Center for Protease Research, Department of Chemistry, Biochemistry and Molecular Biology, North Dakota State University, Fargo, ND 58105, USA. gregory.cook@ndsu.nodak.edu

PMID: 15341955
DOI: 10.1016/j.bmcl.2004.07.023

Abstract

MMP inhibitors with novel oxazoline zinc binding groups have been synthesized and evaluated. Selectivity for the inhibition of MMP-9 over MMP-1, MMP-2, and MMP-12 has been achieved in several cases.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Matrix Metalloproteinase Inhibitors*
Matrix Metalloproteinases / chemistry
Oxazoles / chemical synthesis*
Oxazoles / pharmacology
Protease Inhibitors / chemical synthesis*
Protease Inhibitors / pharmacology
Structure-Activity Relationship

Substances

Matrix Metalloproteinase Inhibitors
Oxazoles
Protease Inhibitors
Matrix Metalloproteinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding