Correlates of benzodiazepine use in individuals with insomnia

Sleep Med. 2004 Sep;5(5):457-62. doi: 10.1016/j.sleep.2004.04.001.

Abstract

Background and purpose: Although benzodiazepines (BZDs) are commonly used in the treatment of insomnia, there is little information about psychological, health, and sociodemographic correlates associated with their use.

Objective: This study examined correlates of benzodiazepine use for sleep in a clinical sample of patients seeking treatment for insomnia at a sleep disorders clinic.

Patients and methods: The sample consisted of 97 individuals evaluated at a sleep disorders clinic for a presenting complaint of insomnia. Two groups were formed, including one with 61 patients who had been using BZDs for sleep for an average of 56.6 months (SD=68.0), and another with 36 patients who had insomnia but were not using BZDs or any other sleep aid. Logistic regressions, adjusting for an age difference between the user and non-user groups, were performed to examine variables associated with BZD use. Independent variables included demographic, medical, insomnia-related and psychological parameters and subjective sleep-wake characteristics. Unadjusted regression analyses were performed to identify factors associated with a pattern of long-term use (>12 months) within the user group.

Results: Age was a significant predictor of BZD use (OR=1.84, P = 0.0002). Significant age-adjusted predictors of BZD use included perceived insomnia severity (OR=1.17, P = 0.038), depressive symptoms, (OR=1.108, P = 0.009) and state and trait anxiety symptoms (OR=1.062, P = 0.016; OR=1.084, P = 0.005, respectively). Significant predictors of long-term use (>12 months) were age of insomnia onset (OR=0.951, P = 0.0214), more frequent BZD use (OR=3.284, P = 0.0221), and higher state-anxiety (OR=1.106, P = 0.0471).

Conclusions: Age, psychological variables and perceived sleep disturbances severity, are associated with BZD use in patients with insomnia.

MeSH terms

  • Adult
  • Age Factors
  • Anti-Anxiety Agents / therapeutic use*
  • Anxiety / diagnosis
  • Anxiety / drug therapy
  • Anxiety / epidemiology
  • Benzodiazepines / therapeutic use*
  • Case-Control Studies
  • Comorbidity
  • Depression / diagnosis
  • Depression / drug therapy
  • Depression / epidemiology
  • Drug Utilization / statistics & numerical data
  • Female
  • Humans
  • Hypnotics and Sedatives / therapeutic use*
  • Long-Term Care
  • Male
  • Middle Aged
  • Regression Analysis
  • Sleep / drug effects
  • Sleep Initiation and Maintenance Disorders / diagnosis
  • Sleep Initiation and Maintenance Disorders / drug therapy*
  • Sleep Initiation and Maintenance Disorders / epidemiology
  • Wakefulness / drug effects

Substances

  • Anti-Anxiety Agents
  • Hypnotics and Sedatives
  • Benzodiazepines