Abstract
Activity is known to be important for the refinement of neural connections in the developing brain. In this issue of Neuron, Hanson and Landmesser provide evidence that GABA-dependent spontaneous bursting of motor neurons in the embryonic spinal cord is required for the correct execution of an early axon pathfinding decision.
MeSH terms
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Action Potentials / physiology*
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Animals
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Cell Communication / physiology
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Cell Differentiation / physiology
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Growth Cones / physiology*
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Growth Cones / ultrastructure
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Humans
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Motor Neurons / cytology
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Motor Neurons / physiology*
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Neural Cell Adhesion Molecule L1 / metabolism
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Neural Inhibition / physiology
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Sialic Acids / metabolism
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Spinal Cord / cytology
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Spinal Cord / embryology*
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Spinal Cord / physiology
Substances
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Neural Cell Adhesion Molecule L1
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Sialic Acids
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polysialyl neural cell adhesion molecule