How early is firing required for wiring?

Neuron. 2004 Sep 2;43(5):601-3. doi: 10.1016/j.neuron.2004.08.027.

Abstract

Activity is known to be important for the refinement of neural connections in the developing brain. In this issue of Neuron, Hanson and Landmesser provide evidence that GABA-dependent spontaneous bursting of motor neurons in the embryonic spinal cord is required for the correct execution of an early axon pathfinding decision.

Publication types

  • Comment
  • Review

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Cell Communication / physiology
  • Cell Differentiation / physiology
  • Growth Cones / physiology*
  • Growth Cones / ultrastructure
  • Humans
  • Motor Neurons / cytology
  • Motor Neurons / physiology*
  • Neural Cell Adhesion Molecule L1 / metabolism
  • Neural Inhibition / physiology
  • Sialic Acids / metabolism
  • Spinal Cord / cytology
  • Spinal Cord / embryology*
  • Spinal Cord / physiology

Substances

  • Neural Cell Adhesion Molecule L1
  • Sialic Acids
  • polysialyl neural cell adhesion molecule