UVB-TL01 is proven to be efficient in whole body treatment for several chronic inflammatory dermatoses. Chronic hand dermatoses of different and often mixed genesis represent a great problem in clinical practice. We have performed a prospective, open study with patients suffering from psoriasis, eczema or pustulosis of the hands treated with hand UVB-TL01. Thirty patients (23 women and 7 men) were included, mean age 43 years (range 25-68 years). The psoriatics were the best responders, as 9 of 11 were improved or much improved after 20-38 treatments, compared to 11 of 16 patients with eczema (11-31 treatments). One of three patients with palmar pustulosis experienced improvement after 23-27 treatments. UVB-TL01 seems to be helpful in the majority of patients with chronic inflammatory diseases of the hands. More extensive studies with regard to proper dosing and length of treatment period ought to be carried out.