Diazepinomicin, a new antimicrobial alkaloid from a marine Micromonospora sp

J Nat Prod. 2004 Aug;67(8):1431-3. doi: 10.1021/np040042r.

Abstract

The structure of a new dibenzodiazepine alkaloid, diazepinomicin (1), isolated from the culture of a marine actinomycete of the genus Micromonospora was characterized using spectroscopic methods. Diazepinomicin represents a unique molecular class composed of a dibenzodiazepine core linked to a farnesyl side chain.

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Dibenzazepines / chemistry
  • Dibenzazepines / isolation & purification*
  • Dibenzazepines / pharmacology
  • Gram-Positive Bacteria / drug effects
  • Japan
  • Microbial Sensitivity Tests
  • Micromonospora / chemistry*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Alkaloids
  • Anti-Bacterial Agents
  • Dibenzazepines
  • diazepinomicin